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EPAC 5376753
CAS No. 302826-61-5
EPAC 5376753 ( 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione )
产品货号. M26202 CAS No. 302826-61-5
EPAC 5376753 是 EPAC1 的变构抑制剂，在 Swiss 3T3 细胞中的 IC50 为 4 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1758 | 有现货 |
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| 10MG | ￥2560 | 有现货 |
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| 25MG | ￥4309 | 有现货 |
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| 50MG | ￥6229 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称EPAC 5376753
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述EPAC 5376753 是 EPAC1 的变构抑制剂，在 Swiss 3T3 细胞中的 IC50 为 4 μM。
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产品描述EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.(In Vitro):EPAC 5376753 decreases the conformational changes of EPAC necessary for its activation. EPAC 5376753 inhibits EPAC signaling in cells and EPAC-mediated migration in fibroblasts.
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体外实验Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts.
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体内实验——
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同义词5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
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通路GPCR/G Protein
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靶点cAMP
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受体P-gp
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研究领域——
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适应症——
化学信息
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CAS Number302826-61-5
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分子量367.2
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分子式C15H8Cl2N2O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESClc1ccc(-c2ccc(C=C3C(=O)NC(=S)NC3=O)o2)c(Cl)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Hongzhi Zhang, et al. Anti-tumor Efficacy of Phellamurin in Osteosarcoma Cells:Involvement of the PI3K/AKT/mTOR Pathway. Eur J Pharmacol. 2019 Sep 5;858:172477.
产品手册
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